According to the Northern Arizona University site on vaginal spermicides, 2 applicators full are needed for women at elevations higher than 3500 feet Protection is immediate and lasts about an hour. Spermicides are not as effective as many other forms of birth control when used alone. Contraceptive gels is over the counter (OTC) birth control method that can be used without doctors prescription. Up-to-date pricing and reviews for contraceptive gels on the market can be found at the many weeks pregnant website.
One can only wonder why the author of the article” failed to describe the woman as blonde” as well.) Jokes about women eating (rather than applying) vaginal gel have been around for years (a similar one was told at Canada’s 1994 Reform Party convention, for example), as have their counterparts (i.e., tales of women who became pregnant after vaginally applying regular” jelly instead of spermicidal gels). In August 2013, we searched the following computerized databases for randomized controlled trials of spermicides for contraception: CENTRAL, MEDLINE , POPLINE, LILACS, EMBASE , , and ICTRP. Gel was liked more than the film or vaginal suppository in the largest trial Spermicide trials have the dual challenges of difficult recruitment and high discontinuation rates; the latter threatens trial validity.
A gel containing nonoxynol-9 52.5 mg was inferior to two other products tested in the largest trial Aside from this finding, personal characteristics and behavior of users may be more important than characteristics of the spermicide products in determining the probability of pregnancy. In August 2013, we did computer searches for randomized trials of spermicides used for birth control We have not found any new trials since the initial review For the initial review , we also wrote to researchers to find other trials. Spermicides contain an active ingredient (usually nonoxynol-9) and something to disperse the product, such as foam or vaginal suppository (pessary).
Currently available spermicides containing nonoxynol-9 are ineffective as microbicides, in particular as HIV-preventive measures.17 Thus, spermicides used alone are not recommended to prevent HIV or other STIs. Frequent use (2 times or more a day) of nonoxynol-9 containing spermicide is inadvisable if STI/HIV exposure is likely, because in this situation there is increased vulvovaginal epithelial disruption and increased risk of HIV acquisition. Spermicides are believed to increase the contraceptive effectiveness of condoms.
Spermicide is a contraceptive substance that destroys sperm , inserted vaginally prior to intercourse to prevent pregnancy As a contraceptive, spermicide may be used alone. At the 2.5% level of significance (one-sided), a sample size of 1002 women in the C31G treatment arm and 668 women in the nonoxynol-9 treatment arm was sufficient to reject, with 80% statistical power, the null hypothesis that the 6-month cumulative pregnancy probability in the C31G treatment arm is more than 5 percentage points greater than that in the Nonoxynol-9 Vaginal Gel treatment arm. Study participants were asked to engage in at least 4 acts of vaginal sexual intercourse per month, use the study product as the primary method of contraception, and keep a diary of coital activity, product use, use of other vaginal products, and adverse events.
Eligibility requirements included being a healthy, sexually active female, 18-40 years old, at risk for pregnancy and desiring contraception, having 24-35 day menstrual cycles, and being at low risk for HIV or other sexually transmitted infection. This study was designed as a Phase III randomized, double-masked, non-inferiority trial to evaluate the contraceptive efficacy of C31G over six months of use (6 cycles and 183 days) compared to a commercially available, nonoxynol-9-based spermicidal gel. We conducted a multicenter, randomized, double-masked trial of C31G spermicidal gel and a commercially available nonoxynol-9 spermicide (Conceptrol®, Ortho, Raritan, NJ) to compare contraceptive efficacy, acceptability, and safety.
We conducted a multicenter, randomized, double-masked, controlled trial to assess whether a gel containing the spermicide C31G was non-inferior to a commercially available product containing nonoxynol-9. A randomized trial of the contraceptive efficacy, acceptability, and safety of C31G and nonoxynol-9 spermicidal gels. The National Institutes of Health is looking for a few good men —and a few brave women — to try out a new birth control gel for males.
“Up until now, the responsibility for contraception has traditionally always been with the female,” study researcher Dr. Christina Wang, a lead investigator at Los Angeles Biomedical Research Institute at UCLA Medical Center, said in a press release “With these new contraceptive methods for males, the responsibility will be shared. (CBS News) A promising new male contraceptive gel may be an alternative method of birth control for couples, researchers announced this week. Blithe says the men are responding positively to the gel, and she’s getting ready to enter the phase of the study that involves female participants abandoning their own birth control to put its effectiveness to the test.
But hormonal birth controls like NES/T, the product Blithe and her colleagues are studying at NIH, are the male contraceptive products furthest along in clinical trials and appear to have the best shot at reaching the market most quickly. The past few decades of research have been able to correct for these problems: Hormonal contraceptives currently being tested for male use—gels, injections, and pills—typically use testosterone in conjunction with a second hormone or hormone compound to stop sperm production while regulating the testosterone levels in the rest of the body. When studies on male birth control resumed in the 70s, led by the NIH, researchers hit on a major breakthrough: With the continued use of testosterone, they could suppress men’s sperm counts to effectively infertile levels.
As of 2014, more than 9.5 million women in the US reported taking the pill, and about 16 million others use some other form of birth control other than condoms, making up a roughly $20 billion industry Despite the breathless way the media has covered incremental developments in the search for an effective male birth control outside of condoms and vasectomies, the question remains: Do men even want it? This lengthy process isn’t exclusive to Blithe’s contraceptive gel: Other male birth control methods, like the pill and the injection , are making their way through this timeline, too, as any first-time drug would have to. This is because the success of male contraception depends on near complete suppression of sperm production while maintaining healthy testosterone levels to maintain a man’s sexual drive (libido).
VCF® Contraceptive Gel is the newest spermicide from the female contraceptive manufacturer of VCF Contraceptive Film and VCF Contraceptive Foam. These Contraceptive Gel Pre-Filled Applicators from VCF use spermicide to help with the prevention of pregnancy and can be used with or without a condom. A safe, highly effective, and reversible method of male contraception would fill an important public health need,” investigator Diana Blithe, PhD, chief of NICHD’s Contraceptive Development Program, said in a press release.
Since many women can’t or don’t want to use hormonal contraception and male contraceptive methods are so limited, this gel is certainly a step in the right direction. In the largest trial to date, the gel (Advantage S) containing the lowest dose of nonoxynol-9 (52.5 mg) was significantly less effective in preventing pregnancy than were gels with higher doses of the same agent (100 mg and 150 mg). In August 2013, we searched the following computerized databases for randomized controlled trials of spermicides for contraception: CENTRAL, MEDLINE, POPLINE, LILACS, EMBASE, , and ICTRP.
Spermicides contain an active ingredient (most commonly nonoxynol-9) and a formulation used to disperse the product, such as foam or vaginal suppository. Contraceptive gels can be used by itself or combine with other birth control method. Contraceptive gels is over the counter (OTC) birth control method that can be used without doctor’s prescription.
The U.S. Food and Drug Administration (FDA) warns that N9 in vaginal contraceptives and spermicides may irritate the lining of the vagina or rectum. Spermicide used with another barrier method (condoms, diaphragm, or cervical cap) is more effective at preventing pregnancy than spermicide alone. This means that in 1 year, 28 out of 100 women who use spermicide as their only method of birth control get pregnant.
Over-the-counter vaginal contraceptive and spermicide drug products containing nonoxynol-9; Required labeling. Using spermicide frequently may increase vaginal irritation, which may increase the risk of contracting HIV or other sexually transmitted infections. Spermicide isn’t a very effective birth control method when used alone.
Do not use VCF Vaginal Contraceptive (nonoxynol 9 gel) rectally. Do not take VCF Vaginal Contraceptive (nonoxynol 9 gel) by mouth. Use VCF Vaginal Contraceptive (nonoxynol 9 gel) as ordered by your doctor.
If you are pregnant or you get pregnant while taking VCF Vaginal Contraceptive (nonoxynol 9 gel), call your doctor right away. Do not use VCF Vaginal Contraceptive (nonoxynol 9 gel) if you are pregnant. If you are allergic to VCF Vaginal Contraceptive (nonoxynol 9 gel); any part of VCF Vaginal Contraceptive (nonoxynol 9 gel); or any other drugs, foods, or substances.
If you have an allergy to nonoxynol 9 or any other part of VCF Vaginal Contraceptive (nonoxynol 9 gel). The method has already been shown to be effective in an initial six-month study But it involved two types of gels that had to be applied to different parts of the body, so Blithe’s team at NIH worked with researchers at the Population Council to reformulate the hormones and combine them into one gel. After more than a decade of work, government researchers in the U.S. are ready to test an unusual birth control method for men—a topical gel that could prevent the production of sperm.
MONDAY, July 2 (HealthDay News) – Men may one day have a birth-control option other than the condom or vasectomy – if early research on a new contraceptive gel pans out. N-9 is found in a variety of vaginal contraceptive products, including creams, foams, gels and suppositories—used alone or in combination with the diaphragm or cervical cap. N-9 spermicides have been available over-the-counter in the United States since the 1960s and are used by approximately half a million women for pregnancy prevention.
Those expectations were dashed, however, when in 2000 a study of N-9’s effectiveness among sex workers in Benin, Cote d’Ivoire, South Africa and Thailand showed that HIV incidence was actually higher among the women using N-9 than among those using a comparison product. The international trial is studying the effectiveness of the hormone gel, called NES/T, by analysing 450 couples who have agreed to use it as their only form of contraception for the next 12 months. There is also a suggestion that using spermicides increases the risk of a urinary tract infection (UTI) in women, potentially by damaging the normal bacterial flora of the vagina and by increasing irritation.
Frequent use of certain spermicides may increase the risk of getting a sexually transmitted infection (STI), including HIV, from an infected partner. If spermicides are used as the only form of contraception, up to 28 per cent of women may become pregnant within a year. Spermicides are applied deep into the vagina, close to the cervix, before sex to prevent sperm from entering the uterus.
Spermicides come in a variety of forms – creams, gels, foams, suppositories, tablets and films – but are currently not available in Australia. Vaginal contraceptive sponges are soft sponges covered with a spermicide. If spermicides are not used correctly, the risk of pregnancy is more than 25 for every 100 women each year.
Health Decisions is a full-service CRO specializing in clinical studies of therapeutics for women’s health indications and studies of diagnostics for all therapeutics areas.” Since its beginning more than 29 years ago, it has conducted over 140 clinical trials in women-only indications, including contraception, high-risk HPV, risk of preterm birth, and STIs. Based on previous surveys, more than 50 percent of men would be interested in using a reversible contraceptive method and many women would feel comfortable relying on an effective, reversible male contraceptive method,” Dart added. Expanding male contraceptive options could help make family planning more of a shared responsibility between women and men,” said Regine Sitruk-Ware, distinguished scientist at the Population Council’s Center for Biomedical Research and world-renowned reproductive endocrinologist who is overseeing trials testing the NES/T gel.
The pregnancy rate (based on the number of pregnancies that occur in the efficacy phase) and rate of compliance with gel usage will be assessed to both measure the gel’s efficacy and gauge the gel’s overall acceptance as a male contraceptive method. This trial will not only test the gel’s efficacy in preventing pregnancy, but also men’s compliance and couple’s acceptance of this contraceptive method, which is critical to real-world applicability and ultimately efficacy. This gel reduces sperm count to a contraceptive level,” Clint Dart, the Vice President, Biostatistics and Programming at Health Decisions (the CRO running the study), exclusively told BioSpace.
A girl shouldn’t douche for at least 6 hours after a couple has sex using spermicide as birth control. Spermicides must be placed in the vagina before sexual intercourse. T-PSS alone or in gel, but not the placebo gel, inhibited hyaluronidase and acrosin, enzymes with putative functions in the fertilization process 53 Inhibitors of these enzymes are known to be contraceptive when placed vaginally 54 , 55 An effect of PSS of unknown molecular mass on the binding of sperm proacrosin to fucoidin, a sulfated polysaccharide, was previously reported 56 Furthermore, both T-PSS alone and the T-PSS gel caused the dispersion of the acrosomes from spermatozoa.
When the contraceptive effect of the T-PSS gel or its placebo was tested, the formulation (0.75 ml) was placed vaginally with a plastic insemination tube past the pelvic bone, followed 15 min later by insemination with 0.5 ml of washed spermatozoa (total: 31 × 106) in the same vaginal location. Our observations suggest that T-PSS is a novel vaginal contraceptive antimicrobial agent and that the gel form should be evaluated for its safety and efficacy in women. Studies focused on the compound in gel because this is the method whereby T-PSS will be used vaginally, but information was also obtained on the compound alone (drug substance) and used for comparative purposes to assess whether the compound retained full effectiveness in the formulation. Be sure to visit many weeks pregnant for the best contraceptive gels on the market to buy.
Sulfated/sulfonated polymers and/or polysaccharides appeared to be compounds that fall into this category because some have been reported to inhibit STD-causing microbes 26 – 29 , whereas others are known to be contraceptive 30 , 31 Our subsequent studies suggested that several of these compounds, including poly(sodium 4-styrenesulfonate; PSS) and cellulose sulfate, have dual activities 32 , 33 Contraceptive antimicrobial agents are of particular clinical interest because consumer preference studies suggest that most women worldwide prefer a vaginal prophylactic product to be both antimicrobial and contraceptive 34 (L. Fransen, European Commission, HIV/AIDS Programme in Developing Countries, News Release, 1998). T-PSS in gel form is worthy of clinical evaluation as a vaginal contraceptive HIV/STD preventative. Of course, reduced sperm count in 89 percent of men isn’t exactly perfect (women using approved birth control experience pregnancy at a rate of just three-tenths of a percent per year, by comparison).